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Reference desk Archives Science 2019 September 23

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= September 23 =

If raffinose can be hydrolysed to galactose (and fructose and glucose), why doesn't raffinose induce the GAL1 promoter?

So many studies use differential galactose/raffinose media where galactose induces the GAL1 promoter but raffinose does not. My instructor is unable to explain why raffinose does not activate the GAL1 promoter if it can be hydrolyzed to galactose inside the cell. Is GAL1 activation dependent on extracellular galactose binding to a transmembrane receptor, which is insensitive to cytosolic galactose? Yanping Nora Soong (talk) 21:53, 23 September 2019 (UTC)
I happen to know an expert on galactose metabolism. His answer to your question, For myself, I'd say I've recently consigned myself to the realization that organisms preferring to ferment under aerobic conditions simply did not evolve to be efficient. They evolved to grow as fast as possible, and this is necessarily wasteful. Someguy1221 (talk) 02:40, 24 September 2019 (UTC)

Thanks so much!! Yanping Nora Soong (talk) 04:32, 24 September 2019 (UTC)


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